Cyclo (His-Pro), or cHP is a metabolite of TRH, and has anorexigenic properties. Pharmacol Biochem Behav. 1991 Feb;38(2):359-64   cHP seems to have a gut and brain distribution, with higher levels of cHP in the lateral hypothalamus of obese Zucker rats.  Brain Res. 1995 Nov 13;699(1):149-53. The raised cHP levels in the hypothalamic nuclei of these obese rats can be down-regulated by DHEA administration.

Although analogs of cyclo-his-pro have been developed, none of them seem superior to cyclo-his-pro itself in appetite suppression. Interestingly, one paradoxically stimulated appetite. Pharmacol Biochem Behav. 1991 Feb;38(2):359-64      The cyclo-diketopiperazine molecule, cyclo-Asp-Pro which is derived from Enterostatin  Peptides. 1994;15(5):849-54.   also has suppressive effects on food intake on peripheral or central administration,  with greater potency and specificity for fat intake reduction than cyclo-his-pro.

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