Guthormones Adipokines Neuropeptides and the cause of Obesity

•Affects 2-3% of the UK population.

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•1.8 million diabetics in the UK

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1 million are undiagnosed.

•Expected to affect 20% of men and 25% women by 2005

•By year 2030 it is estimated that 50% of the UK population will be obese.

•First cases of type 2 diabetes found in white UK teenagers (Archives of Disease in Childhood (2002;86:207-8 )

•Diabetes is expected to affect 3% of UK population by 2010

Over a ten-year period obese people with a BMI > 35 are up to 80 times more likely to develop the diabetes than someone with a BMI of less than 22.

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•1 in 20 people above the age of 65 have diabetes.

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•1 in 5 people above the age of 85 have diabetes.

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•One in 10 acute medical beds is occupied by diabetic patients.

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•Life expectancy is reduced by 20 years in type 1 diabetes and 10 years in type 2 diabetes

•Diabetes is the commonest medical problem complicating pregnancy.

•One in 250 pregnancies is complicated by diabetes.

• Perinatal mortality is 5 times higher in babies of diabetic mothers.

•In the UK around 3200 people with diabetes are on renal replacement therapy (dialysis and transplant)

•An average 1000 new diabetic patients begin renal replacement therapy each year.

•Direct costs due to diabetes: £2000 annually/patient

–NHS spending 80%

–Private expenditure 13%

–Social services 7%

•Indirect costs -–1 in 3 patients need a carer; the need for a carer is doubled by the presence of complications